Discovery of novel non-synonymous SNP variants in 988 candidate genes from 6 centenarians by target capture and next-generation sequencing
نویسندگان
چکیده
منابع مشابه
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Whole exome sequencing (WES) is a widely used strategy for detection of protein coding and splicing variants associated with inherited diseases. Many studies have shown that the strategy has been broad and proficient due to its ability in detecting a high proportion of disease causing variants, using only a small portion of the genome. In this review we outline the main steps involved in WES, t...
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ژورنال
عنوان ژورنال: Mechanisms of Ageing and Development
سال: 2013
ISSN: 0047-6374
DOI: 10.1016/j.mad.2013.01.005